Fatty liver in pregnancy may increase risk of preterm birth: Study

Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study on Friday. 

It is estimated that as many as three out of ten people globally have MASLD, previously called non-alcoholic fatty liver disease. Common risk factors are metabolic disorders such as Type 2 diabetes and overweight or obesity.

The disease has become increasingly common, including among women of reproductive age.

Researchers from Karolinska Institutet in Sweden have now investigated the association between maternal MASLD and pregnancy and neonatal birth outcomes.

Their findings, published in the journal eClinicalMedicine, showed that women with MASLD were more than three times more likely to give birth prematurely.

The risk did not increase with MASLD severity and the increase in risk persisted even when compared to overweight or obese women without known MASLD.

“This suggests that the association is not only due to a high body mass index (BMI) and that the liver disease itself can have negative effects,” explains lead author Carole A. Marxer, a postdoctoral researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.

The study is based on Swedish registry data and includes a total of 240 births among women with MASLD and 1,140 matched births of women from the general population.

Women with MASLD also had a 63 per cent higher risk of caesarean section than the control group. However, this seems to be explained by high BMI as no increase in risk was seen compared to overweight or obese women without fatty liver disease.

“It is important that pregnant women with MASLD are closely monitored during pregnancy to reduce the risk of complications. Consideration should also be given to adding specific recommendations for pregnant women to the clinical guidelines for MASLD,” Marxer said.

“It is also worth noting that we did not find any increased risk in women with MASLD of having children with congenital malformations or of having children who died at birth,” added Jonas F. Ludvigsson, paediatrician at Orebro University Hospital and professor at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.

However, the increased risk may have been influenced by other factors as well, the researchers said.

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